منابع مشابه
Functional genomics in the mouse: phenotype-based mutagenesis screens.
Significant progress has been made in sequencing the genomes of several model organisms, and efforts are now underway to complete the sequencing of the human genome. In parallel with this effort, new approaches are being developed for the elucidation of the functional content of the human genome. The mouse will have an important role in this phase of the genome project as a model system. In thi...
متن کاملPhenotypic Screens, Chemical Genomics, and Antimalarial Lead Discovery
Several extensive small molecule screens against growing Plasmodium falciparum have recently been published [1–3] and thousands of hit structures are now publicly available. This represents a large majority of the drug-like chemical diversity currently available for screening and hence delineates the currently drugable target space of P. falciparum, since the ‘‘drugability’’ term includes an ‘‘...
متن کاملGenome-wide high-throughput screens in functional genomics.
The availability of complete genome sequences from many organisms has yielded the ability to perform high-throughput, genome-wide screens of gene function. Within the past year, rapid advances have been made towards this goal in many major model systems, including yeast, worms, flies, and mammals. Yeast genome-wide screens have taken advantage of libraries of deletion strains, but RNA-interfere...
متن کاملFrom screens to genes: prospects for insertional mutagenesis in zebrafish.
The systematic, and now classic, genetic screens for mutations affecting the development of Drosophila and Caenorhabditis elegans have laid the foundation for the study of developmental mechanisms in these invertebrates (N/isslein-Volhard and Wieschaus 1980; Horvitz and Sternberg 1991). The subsequent molecular isolation and characterization of the affected genes has allowed a thorough understa...
متن کاملGenes, Genomes and Genomics
Invited Review: Reproducible and target-specific polymerase chain reaction (PCR) amplification relies on several interrelated factors of which primer design is central. Here, we describe new free bioinformatics software, the FastPCR which was developed, and continues to be updated, based on detailed experimental studies of PCR efficiency for the optimal design of primers and probe sequences and...
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ژورنال
عنوان ژورنال: Cancer and Metastasis Reviews
سال: 2012
ISSN: 0167-7659,1573-7233
DOI: 10.1007/s10555-012-9362-z